Intraoperative Fentanyl Dose on Respiratory Complications

Status unconfirmed

Conditions studied: Fentanyl, Opioid Use, Surgery, Respiratory Complication

In brief

Fentanyl is the most commonly used opioid during anesthesia at Massachusetts General Hospital. Compared to other opioids, e.g. sulfentanil and remifentanil, fentanyl's pharmacokinetic properties are more problematic as the context sensitive half-time increases with duration of fentanyl infusion. This may lead to respiratory complications particularly in patients who receive fentanyl for surgical procedures of long duration. Considering the common use of fentanyl during surgery and its duration of action that is hard to predict during long surgical procedures, we will evaluate the association between intraoperative fentanyl dose and postoperative respiratory complications within 3 days of surgery.

Key facts

Study ID

NCT03198208

Run by

Massachusetts General Hospital

People needed

183396

Starts

2007-01-01

Expected to finish

2018-06-30

Last updated by the study team

2017-06-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Surgical patients at Massachusetts General Hospital and two affiliated community hospitals
• 18 years of age and older
• Only patients who required general anesthesia with an endotracheal tube for the surgical procedure and were extubated in the operating room at the end of the procedure.

You may not qualify if…

• Brain dead patients (ASA greater than 5)

Where it is running

• The Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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