Effect of Ghrelin on Decision-Making

Withdrawn before enrolling · Phase 1

Conditions studied: Healthy Volunteers, Obesity

In brief

This study evaluates the effect of the "hunger hormone" ghrelin on human decision-making. Participants will be given an injection of ghrelin or saline on different study days and will then be asked to make a series of computer-based decisions. The investigators hypothesize that ghrelin will increase participant's preference for energy-dense foods and will also increase impulsiveness in decision making.

Key facts

Study ID

NCT03198143

Run by

Jenny Tong, MD, MPH

People needed

0

Starts

2019-10-01

Expected to finish

2022-02-01

Last updated by the study team

2020-01-27

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ability to speak and understand English
• BMI of 18.0 - 24.9 kg/m2 or 30.0 - 50.0 kg/m2

You may not qualify if…

• Diagnosis of diabetes mellitus (including gestational diabetes)
• Active infections
• History of malignant or inflammatory conditions, such as rheumatoid arthritis and inflammatory bowel disease
• History of myocardial infarction or congestive heart failure
• Active liver or kidney disease
• Uncontrolled hypertension
• Pituitary or adrenal disorders or neuroendocrine tumors
• History of anorexia nervosa, bulimia, or eating disorders not otherwise specified (NOS); Score of "at risk" on the EAT-26 eating disorder screening tool
• Diagnosis of attention-deficient/hyperactivity disorder (ADHD)
• Malabsorptive gastrointestinal disease, gastroparesis, or history of gastrointestinal surgery
• Pregnancy or lactation
• Requirement of daily medications that alter gastrointestinal function (including, but not limited to, glucocorticoids, psychotropics, narcotics, and metoclopramide).
• Requirement of glasses for impaired vision (including reading glasses). Subjects who wear contact lenses for vision correction will not be excluded.
• Insufficient visual acuity to read and interpret the decision stimuli
• Insufficient motor capabilities to press a button, move the joystick, or move their eyes to indicate a response

Where it is running

• Duke Sociology-Psychology Building 417 Chapel Drive — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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