Early Rheumatoid Arthritis Lung Disease Study

Recruiting now

Conditions studied: Rheumatoid Arthritis

In brief

Extra-articular (outside of joints) disease occurs in approximately 50% of rheumatoid arthritis (RA) patients, with the lung being a common site of involvement. The goals of this study are to investigate and characterize lung disease and its prevalence in early RA participants. This will be done through pulmonary function and high resolution chest computed tomography (CT), questionnaires, and serum studies. Another goal is to find novel biomarkers, such anti-malondialdehyde-acetaldehyde (MAA) antibodies, as predictors of lung disease in RA participants.

Key facts

Study ID

NCT03192267

Run by

University of Nebraska

People needed

125

Starts

2017-03-31

Expected to finish

2030-03-01

Last updated by the study team

2026-07-09

Who can join

Age: 19 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 19-90 years of age
• Able to give informed consent
• Diagnosis of RA by a Rheumatologist using 2010 American College of Rheumatology (ACR) criteria within the past 2 years

You may not qualify if…

• Inflammatory arthritis that does not meet 2010 American College of Rheumatology (ACR) criteria for rheumatoid arthritis (RA)
• Pregnant

Where it is running

• University of Nebraska Medical Center — Omaha, Nebraska, United States (enrolling)

Full record on ClinicalTrials.gov

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