Efficacy, Safety, and Pharmacokinetics of APT-1011 in Subjects With Eosinophilic Esophagitis (EoE)

Completed · Phase 2 · Has a placebo group

Conditions studied: Eosinophilic Esophagitis

In brief

Eosinophilic esophagitis (EoE) is an inflammatory disease of the esophagus, characterized by eosinophilic infiltration and gastrointestinal symptoms. Swallowed, topically acting corticosteroids, such as fluticasone, appear to be effective in resolving acute clinical and pathological features of EoE. APT-1011 is an orally disintegrating tablet (ODT) formulation of fluticasone propionate. This study is designed to compare the efficacy and safety of APT-1011 with placebo in adults with EoE for an initial 12-week treatment period, followed by an additional 40-week maintenance treatment phase. Histologic response, pharmacokinetics, and dysphagia will be assessed.

Key facts

Study ID

NCT03191864

Run by

Adare Pharmaceuticals, Inc.

People needed

106

Starts

2017-06-22

Expected to finish

2019-10-23

Last updated by the study team

2023-04-26

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female between ≥18 and ≤75 years of age at the time of informed consent
• Signed informed consent
• Evidence of EoE defined by ≥15 peak eosinophils per HPF as measured from proximal and distal biopsies
• Subject-reported history of ≥3 episodes of dysphagia in the 7 days prior to Screening
• 7-day Global EoE Symptom Score >3 at baseline and at screening
• Willing and able to adhere to study-related treatment regimens, procedures, and visit schedule

You may not qualify if…

• Have known contraindication, hypersensitivity, or intolerance to corticosteroids;
• Have any physical, mental, or social condition or history of illness or laboratory abnormality that in the Investigator's judgment might interfere with study procedures or the ability of the subject to adhere to and complete the study;
• Presence of oral or esophageal mucosal infection of any type;
• Have any mouth or dental condition that prevents normal eating;
• Have any condition affecting the esophageal mucosa or altering esophageal motility other than EoE;
• Use of systemic corticosteroids within 60 days prior to Screening, use of inhaled/swallowed corticosteroids within 30 days prior to Screening, or extended use of high-potency dermal topical corticosteroids within 30 days prior to Screening;
• Initiation of an elimination diet or elemental diet within 30 days before Screening (diet must remain stable after signing ICF);
• Morning serum cortisol level ≤5 μg/dL (138 nmol/L);
• Use of biologic immunomodulators in the 24 weeks prior to Screening;
• Use of calcineurin inhibitors or purine analogues, or potent cytochrome P450 (CYP) 3A4 inhibitors in the 12 weeks prior to Screening;
• Have a contraindication to or factors that substantially increase the risk of EGD or esophageal biopsy or have narrowing of the esophagus that precludes EGD with a standard 9 mm endoscope;
• Have a history of an esophageal stricture requiring dilatation within the previous 12 weeks prior to Screening;
• Have initiated, discontinued or changed dosage regimen of PPIs, H2 antagonists, antacids or antihistamines for any condition such as GERD or allergic rhinitis within 4 weeks prior to qualifying endoscopy. These drugs must remain constant throughout the study.
• A serum cortisol level <18 μg/dL (497 nmol/L) at 60 minutes with adrenocorticotropic hormone (ACTH) stimulation test using 250 μg cosyntropin (i.e., a positive result on the ACTH stimulation test).

Where it is running

• Del Sol Research Management, LLC — Tucson, Arizona, United States
• Arkansas Gastroenterology, P.A. — Sherwood, Arkansas, United States
• Hope Clinical Research — Canoga Park, California, United States
• TriWest Research Associates, LLC — El Cajon, California, United States
• SC Clinical Research, Inc. — Garden Grove, California, United States
• Beverly Hills Center for Digestive Health — Los Angeles, California, United States
• Focilmed — Oxnard, California, United States
• Precision Research Institute, LLC — San Diego, California, United States
• Medical Associates Research Group, Inc. — San Diego, California, United States
• Care Access Research LLC — San Pablo, California, United States
• Stanford University School of Medicine — Stanford, California, United States
• St. Jude Healthcare — Yorba Linda, California, United States
• Western Connecticut Health Network — Danbury, Connecticut, United States
• Medical Research Center of Connecticut, LLC — Hamden, Connecticut, United States
• Eastern Research, Inc. — Hialeah, Florida, United States
• Nature Coast Clinical Research, LLC — Inverness, Florida, United States
• Sunrise Medical Research — Lauderdale Lakes, Florida, United States
• DBC Research, Corp — Pembroke Pines, Florida, United States
• Northwestern Medical Faculty Foundation — Chicago, Illinois, United States
• Southwest Gastroenterology — Oak Lawn, Illinois, United States
• Rockford Gastroenterology Associates, Ltd. — Rockford, Illinois, United States
• MediSphere Medical Research Center, an AMR affiliate — Evansville, Indiana, United States
• Cotton-O'Neil Clinical Research Center, Digestive Health — Topeka, Kansas, United States
• Gastroenterology Associates — Hazard, Kentucky, United States
• Del Sol Research Management, LLC — Chandler, Arizona, United States

Full record on ClinicalTrials.gov

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