Dietary Sodium (DS) Intervention to Reduce Volume Overload and Tissue Sodium in Magnetic Resonance Imaging (MRI) for Hemodialysis (HD) Patients

Status unconfirmed · Not applicable

Conditions studied: Kidney Failure, Chronic, Dietary Modification

In brief

Sodium-adapted magnetic resonance imaging (23Na-MRI) studies have demonstrated that sodium accumulates in certain tissues, including the skin and skeletal muscle, but may be manipulated by lifestyle factors or therapeutic interventions such as a hemodialysis (HD) session. This tissue sodium accumulation is increased with age and in the presence of certain chronic diseases such as renal failure, and may contribute to the development of high blood pressure. It currently not known what the impact of dietary sodium consumption has on tissue sodium in HD patient's and on the subsequent risk of cardiovascular complications either acutely or chronically. The University of Illinois' Biomedical Imaging Center recently completed safety testing on a 23Na-MRI coil that they modified for measuring skin and muscle sodium levels in the lower leg/calf that will be used for assessing the impact of dietary salt restriction on tissue sodium levels.

Key facts

Study ID

NCT03189758

Run by

University of Illinois at Urbana-Champaign

People needed

20

Starts

2017-06-19

Expected to finish

2021-12-31

Last updated by the study team

2020-08-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Willingness to sign informed consent document and age 18 or greater.
• Willingness to consume intervention meals 3 times per day (with provided snacks) for 30 days.

You may not qualify if…

• Individuals with pacemakers (exclusion from cardiovascular testing only)
• Individuals with major amputations (i.e. whole limb: foot, ankle, leg, arm)
• Individuals with ferric metal implants or devices in the body (excluded from MRI testing only)
• Claustrophobic individuals (excluded from MRI testing only)
• Individuals that do not otherwise meet MRI screening requirements (mentioned below, excluded from MRI testing only)
• Individuals on HD therapy <3 days per week or <3 months
• Currently following a sodium restricted diet approximately <1,500 mg per day (only excluded from MRI analysis)
• Currently diagnosed GI disorder or disease or infection

Where it is running

• University of Illinois at Urbana-Champaign — Urbana, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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