The Effect of Cryotherapy on Cerebral Hemodynamics Within Healthy Subjects

Completed · Phase 1

Conditions studied: Cryotherapy Effect, Oxygen Deficiency

In brief

Upon suffering a concussion, a neurometabolic cascade including an increase in glucose and oxygen demand occurs for up to 48 hours post-insult.5 This period of increased glucose and oxygen demand is coupled with a period of hyperperfusion and decreased cerebral blood flow. 6-9 Cryotherapy in the musculoskeletal system has been shown to decrease tissue temperature, blood flow, oxygen and metabolic demands.10-17 Cryotherapy following moderate or severe traumatic brain injury has been demonstrated to decrease intracranial metabolic processes and oxygenation consumption.18-23 Although the benefits of cryotherapy have been established in moderate-severe TBI, the effects of superficial cranial cooling in individuals with and without concussion are unknown. The purpose of this randomized control trial is to evaluate the effects of superficial cryotherapy on cerebral blood flow and cognitive function in healthy, recreationally active young adults.

Key facts

Study ID

NCT03185507

Run by

University of Virginia

People needed

34

Starts

2017-03-22

Expected to finish

2018-03-13

Last updated by the study team

2018-08-02

Who can join

Age: 18 and older, up to 25. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between 18 and 25 years of age
• Recreationally active (exercise at least 30 minutes, 3 times weekly)

You may not qualify if…

• Contraindications for cryotherapy (eg. Raynaud's phenomenon, cold urticaria)
• Any documented learning difficulty or disability
• Any known neurological or psychiatric disorder
• History of migraines
• History of a concussion or traumatic brain injury in past 6 months
• Currently taking psychotropic medications
• Any known metabolism diseases
• Any known hematological diseases
• Any recreational drug use in past month
• Any known cardiopulmonary impairments or pathologies

Where it is running

• University of Virginia Memorial Gymnasium — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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