Cardiac Magnetic Resonance Imaging After Cardiac Resynchronization Therapy

Status unconfirmed · Not applicable

Conditions studied: Heart Failure, Systolic

In brief

This study is evaluating how MRI after CRT can provide key insights regarding LV function, structure, and mechanics resulting from CRT in patients with or without LV scar and inform optimal pacing strategies. The expected accurate and reproducible response assessment with cardiac MRI has important implications for evaluating CRT outcomes in clinical trials, and the insights from the post-CRT MRI promise to improve implementation of CRT.

Key facts

Study ID

NCT03183011

Run by

Kenneth Bilchick, MD

People needed

40

Starts

2016-11-01

Expected to finish

2018-12-31

Last updated by the study team

2017-06-12

Who can join

Age: 25 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Chronic systolic HF
• LVEF 35% or less
• Guideline-based class I or IIa indication for CRT
• 25 and 85 years old
• Predominantly in sinus rhythm
• GFR ≥ 40 ml/min/1.73m2* *Contrast will not be given for the 6-month follow-up scan if the GFR falls to < 40 ml/min/1.73m2.

You may not qualify if…

• Inability to provide informed consent
• Pregnancy
• Presence of metal embedded in the body due to prior accident or injury, as documented by skull films or other imaging
• Preexisting pacemaker or defibrillator prior to enrollment
• Cerebral aneurysm clips; 6) cochlear implants
• Other metallic implants (prior to enrollment) known to be contraindications to MRI
• Severe claustrophobia
• Acute kidney injury
• Acute renal failure or chronic kidney disease with GFR < 40 cc/min
• Liver transplant
• Gadolinium allergy

Where it is running

• University of Virginia Health System — Charlottesville, Virginia, United States (enrolling)

Full record on ClinicalTrials.gov

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