Liposomal Bupivacaine Versus Standard Bupivacaine in the Adductor Canal for Total Knee Arthroplasty

Stopped early · Phase 4

Conditions studied: Pain

In brief

Study will evaluate the effect of liposomal bupivacaine versus standard bupivacaine on physical therapy measures and pain scores as well as opiate consumption.

Key facts

Study ID

NCT03182933

Run by

University of Wisconsin, Madison

People needed

64

Starts

2017-05-30

Expected to finish

2018-07-16

Last updated by the study team

2019-06-25

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The subject is scheduled for elective unilateral TKA;
• The subject is ≥ 18 years and ≤ 80 years;
• The subject's weight is between 65-130 kg;
• The subject's primary anesthesia care team has planned for a neuraxial anesthetic (i.e. spinal, epidural or combined-spinal epidural);
• The patient agrees to receive an adductor canal block;
• American Society of Anesthesiologists class 1-3.

You may not qualify if…

• Subject is < 18 years of age or >80 years of age;
• Subject is non-English speaking;
• Subject is known or believed to be pregnant;
• Subject is a prisoner;
• Subject has impaired decision-making capacity per discretion of the Investigator;
• Symptomatic untreated gastroesophageal reflux or otherwise at risk for perioperative aspiration;
• Any condition for which the primary anesthesia care team deems neuraxial anesthesia inappropriate;
• Significant pre-existing neuropathy on the operative limb;
• Significant renal, cardiac or hepatic disease per discretion of the investigator;
• American Society of Anesthesiologists class 4-5;
• Known hypersensitivity and/or allergies to local anesthetics;
• Chronic Opioid Use (daily or almost daily use of opioids for > 3 months).

Where it is running

• The American Center — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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