Natural History of Granulomatosis With Polyangiitis: Clinical and Genetic Biomarkers of Airway Disease NoAAC PR-03 Study

Withdrawn before enrolling

Conditions studied: Granulomatosis With Polyangiitis

In brief

The ultimate goal of this prospective natural history study is to define the natural history of the obstructive airway manifestations of Granulomatosis with polyangiitis (GPA). Additionally this proposal seeks to develop biomarkers of disease activity and define their correlation with clinical outcomes in an effort to transform clinical care and shape future drug development for this devastating rare disease.

Key facts

Study ID

NCT03182049

Run by

Vanderbilt University Medical Center

People needed

0

Starts

2020-12-01

Expected to finish

2023-05-01

Last updated by the study team

2020-08-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Greater than or equal to 18 years of age.
• Stenotic Airway Disease (laryngeal, subglottic, distal tracheal or bronchial)

You may not qualify if…

• <18years of age
• Patients without capacity to consent for themselves
• History of significant laryngotracheal traumatic injury.
• Endotracheal intubation 2 years prior to presentation.
• Major anterior neck surgery.
• History of neck irradiation.
• History of caustic or thermal injury to the laryngotracheal complex.

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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