Sedation Administration Timing: Intermittent Dosing Reduces Time to Extubation
Status unconfirmed · Not applicable
Conditions studied: Respiration, Artificial, Postoperative Pain, Postoperative Complications
In brief
SATIRE is a prospective, randomized control trial assessing two methods of administration of intravenous sedation and narcotics in surgical patients requiring mechanical ventilation. Many hospitals use a continuous infusion method of administering these medications. The investigators hypothesize that intermittent, bolus/sliding-scale based administration will lead to less medication being given and subsequently decrease the amount of time on mechanical ventilation without compromising patient comfort or level of sedation. Patients are randomized into a control arm (continuous infusion) and a trial arm (sliding scale hourly bolus) using versed for sedation and fentanyl for pain medication. Inclusion criteria are surgical patients requiring mechanical ventilation, including trauma patients, post operative patients, etc. Primary end point is total time of mechanical ventilation in each arm. Secondary end points are amount of medication given, time in ICU, time to discharge. Mortality and adverse events in both arms are recorded and reported to the Institutional Review Board for monitoring.
Key facts
- Study ID
- NCT03181620
- Run by
- Abington Memorial Hospital
- People needed
- 200
- Starts
- 2016-09-08
- Expected to finish
- 2019-04-01
- Last updated by the study team
- 2019-01-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Mechanical ventilation in the Surgical ICU.
- Age >18 years old
You may not qualify if…
- Use of dexmedetomidine (Precedex®)
- Use of neuromuscular blocking agents
- Use of propofol >24 hours
- Discontinuation of midazolam as sedative (i.e., switching to propofol or dexmedetomidine)
- Therapeutic hypothermia
- Patients that do not require sedatives/narcotics while intubated (i.e. coma, traumatic brain injury)
- Pregnancy
- Prisoners
- Patients with target RASS of -3 to -5 (Deep Sedation)
Where it is running
- Abington Memorial Hospital — Abington, Pennsylvania, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.