Health, Fitness, and Quality of Life in Adolescent Girls With Turner Syndrome

Completed

Conditions studied: Turner Syndrome, Turner Syndrome Mosaicism, 45, X/46, XX or XY, Turner Syndrome Mosaicism 46,X,I(X)(Q10)/45,X, Turner Syndrome Karyotype 46,X With Abnormal Sex Chromosome , Except I(Xq)

In brief

This study plans to learn more about how the energy system works in girls with Turner syndrome. This is important to know so that the investigators understand how Turner syndrome relates to diseases such as diabetes, extra weight gain, heart disease and liver disease, and how this impacts day to day life.

Key facts

Study ID

NCT03181230

Run by

University of Colorado, Denver

People needed

21

Starts

2017-05-26

Expected to finish

2018-12-31

Last updated by the study team

2021-05-03

Who can join

Age: 12 and older, up to 21. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female
• Age 12-21 years
• 45,XO karyotype in >50% of cells tested with a diagnosis of Turner syndrome (TS)
• Tanner stage 2-5 for breast development

You may not qualify if…

• Growth hormone treatment within the past 3 months
• Diagnosis of type 1 or type 2 diabetes
• Untreated hypertension with blood pressure > 99%ile for sex, age and height or >140/90
• Weight > 300 lbs
• Height < 54"
• Aortic sinus of Valsalva or ascending aorta z-score > 2
• Other cognitive, psychiatric, or physical impairment resulting in inability to tolerate the study procedures, including vigorous exercise
• Pregnancy

Where it is running

• Children's Hospital Colorado — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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