Study to Evaluate the Safety and Efficacy of Switching to Tenofovir Alafenamide (TAF) From Tenofovir Disoproxil Fumarate (TDF) and/or Other Oral Antiviral Treatment (OAV)
Completed · Phase 2
Conditions studied: Chronic Hepatitis B
In brief
The primary objective of this study is to evaluate the safety and tolerability and virologic response of tenofovir alafenamide (TAF) in virologically suppressed chronic hepatitis B participants with renal and/or hepatic impairment.
Key facts
- Study ID
- NCT03180619
- Run by
- Gilead Sciences
- People needed
- 124
- Starts
- 2017-06-29
- Expected to finish
- 2020-09-04
- Last updated by the study team
- 2021-09-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Coalition of Inclusive Medicine — Los Angeles, California, United States
- Silicon Valley Research Institute, Inc — San Jose, California, United States
- Henry Ford Health System — Detroit, Michigan, United States
- Harborview Medical Center — Seattle, Washington, United States
- University of Calgary Liver Unit — Calgary, Canada
- Centre de Recherche du Centre Hospitalier de l'Universite de Montreal — Montreal, Canada
- University Health Network,Toronto general Hospital,Toronto centre for liver disease — Toronto, Canada
- Toronto Liver Centre — Toronto, Canada
- (G.I.R.I.) GI Research Institute — Vancouver, Canada
- Prince of Wales Hospital — Shatin, NT, Hong Kong
- Princess Margaret Hospital — Kowloon, Hong Kong
- Alice Ho Miu Ling Nethersole Hospital — Tai Po, Hong Kong
- U.O. Medicina Generale Epatologia IRCCS Humanitas Centro di Ricerca Traslazionale in Epatologia — Rozzano, Milan, Italy
- Dipartimento di Scienze Mediche e Chirurgiche (DIMEC) AOU Policlinico S.Orsola-Malpighi di Bologna — Bologna, Italy
- UOC Gastroenterol-Epatol.-Fondazione IRCCS Ca Granda — Milan, Italy
- Auckland Clinical Studies — Grafton, Auckland, New Zealand
- Dong-A University Hospital — Busan, South Korea
- Pusan National University Hospital — Busan, South Korea
- Asan Medical Center — Seoul, South Korea
- Yonsei University Health System, Severance Hospital — Seoul, South Korea
- Changhua Christian Hospital — Changhua, Taiwan
- Ditmanson Medical Foundation Chia-Yi Christian Hospital — Chiayi City, Taiwan
- Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan
- Kaohsiung Chang Gung Memorial Hospital — Kaohsiung City, Taiwan
- Taichung Veterans Genl Hosp — Taichung, Taiwan
Full record on ClinicalTrials.gov
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