Randomized Fracture Liaison Services

Enrolling by invitation

Conditions studied: Osteoporosis Fracture

In brief

Aims: To compare clinical outcomes for patients under FLS and usual care at the NTUH MH and BB. Method: Four hundred subjects with new hip fracture or newly identified vertebral fracture are randomly assigned into FLS and usual care (UC). FLS subjects received osteoporosis-related assessments, treatments, consultations on diet, medications, exercise, fall preventions given mainly by care managers with followed up telephone call at 4, 8, 12, 18, 24 months then annually for up to 10 years. Care managers will perform baseline assessments and follow them by telephone annually for up to 10 years for UC subjects. Major outcomes include bone mineral density assessment rate, calcium, vitamin D, and osteoporosis medication initiation and adherence rate, fall and fracture incidences, mortality, and healthcare resource utilizations.

Key facts

Study ID

NCT03178799

Run by

National Taiwan University Hospital

People needed

400

Starts

2017-06-23

Expected to finish

2028-12-31

Last updated by the study team

2026-05-18

Who can join

Age: 50 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Traumatic or pathologic fractures
• Atypical femoral shaft fracture
• Participating in other medication intervention trials
• Less than 2 years of life expectancy judged by team physicians
• Incapable of accepting evaluation for cognitive, communication, and physical problems judged by team physicians or coordinators.

Where it is running

• National Taiwan University Hospital — Taipei, Taiwan

Full record on ClinicalTrials.gov

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