The Effect of Manipulation of the Cervical Spine on Pain Biomarkers

Completed · Not applicable · Has a placebo group

Conditions studied: Neck Pain, Posterior

In brief

This study evaluates the effect of high-velocity low-amplitude thrust (HVLAT) manipulation to the cervical spine on neuropeptide expression as determined by the plasma concentration of oxytocin, neurotensin, orexin A and cortisol; and Examine the effect of HVLAT manipulation on pain perception in symptomatic females with non-specific mechanical cervical spine pain

Key facts

Study ID

NCT03176654

Run by

Loma Linda University

People needed

28

Starts

2016-08-15

Expected to finish

2016-09-20

Last updated by the study team

2019-08-01

Who can join

Age: 20 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• 20 - 45 years of age
• A score of 10 or more out of 50 on the Neck Disability Index (NDI) questionnaire
• Symptoms of pain present for 30 days or less and no pain symptoms below your shoulder

You may not qualify if…

• Serious condition (such as cancer, spondylolisthesis, rheumatoid arthritis, or ankylosing spondylitis)
• Cervical spinal stenosis signs (such as incoordination in hands, arms and legs, inability of walking at a brisk pace, or bowel and bladder incontinence)
• Nerve root compression (such as changes in sensation, muscle weakness, or decreased reflexes)
• Works the night shift
• Steroid medication within 3 months
• Pregnancy or postpartum
• Pending legal action regarding their neck pain
• History of whiplash associated disorder and/or cervical spine surgery

Where it is running

• Loma Linda University — Loma Linda, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.