Image-Based Quantitative Assessment of Acute Radiation-Induced Changes in Glioma
Stopped early · Not applicable
Conditions studied: Glioma
In brief
The overall goal of this study is to determine if quantitative imaging techniques can be used to detect dynamic changes of morphology and different physiologic properties of the tumor during and after completion of radiation treatment and to predict site and time of radiation.
Key facts
- Study ID
- NCT03168919
- Run by
- University of Alabama at Birmingham
- People needed
- 5
- Starts
- 2016-10-06
- Expected to finish
- 2018-06-12
- Last updated by the study team
- 2019-10-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Newly diagnosed glioma, based on pathology confirmation;
- At least 8 cm3 of residual enhancing tumor after surgery or significant visible tumor (As seen on immediate postoperative scan);
- Scheduled to receive standard fractionated RT with concomitant temozolomide therapy;
- Karnofsky Performance Score > 60.
You may not qualify if…
- Scheduled to receive investigational chemotherapy, immunotherapy, or any other investigational agents;
- Placement of GLIADEL® wafer in the resection cavity;
- Significant amount of hemorrhage within the resection cavity (seen on immediate post-operative scan);
- A large peritumoral infraction related to surgery (identified by new confluent diffusion restriction);
- Not suitable to undergo MRI or use the MRI contrast agent (GFR<30 mL/min/1.73 m2); or the patient has known anaphylactic reaction to gadolinium based contrast agents.
- Presence of serious systemic illness, including: uncontrolled infection, uncontrolled malignancy, significant renal disease, or psychiatric/social situations, which might impact the survival endpoint of the study or limit compliance with study requirements.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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