Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function
Stopped early · Phase 1
Conditions studied: Smoking, Endothelial Dysfunction
In brief
Hookah (water pipe) smoking is a new global epidemic. The World Health Organization wants to prohibit all claims that hookah is less harmful than cigarettes and wants hookah products to bear the same warning labels as cigarettes. But there is little scientific evidence to substantiate this proposal. Cigarettes, cigars, medicinal nicotine, and e-cigarettes all acutely impair brachial artery endothelial function (flow-mediated dilation, FMD). Also, cigarettes cause both acute and chronic impairment in coronary endothelial function, but the comparative effects of hookah are unknown. Hookah tobacco is heated with burning charcoal. So, the smoke contains "tar" and nicotine plus charcoal combustion products. These include carbon monoxide (CO) and proatherogenic oxidants (especially carbon-rich nanoparticles) that the study team expected to impair endothelial function.
Key facts
- Study ID
- NCT03166787
- Run by
- Cedars-Sinai Medical Center
- People needed
- 60
- Starts
- 2017-08-15
- Expected to finish
- 2020-10-15
- Last updated by the study team
- 2021-04-09
Who can join
Age: 21 and older, up to 49. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 21-25 y/o hookah smokers: smoked hookah > 12 times in the last 12 months.
- 21-25 y/o cigarette smokers: smoked >100 cigarettes and smoked in the last 30 days.
- 35-49 y/o hookah smokers: smoke hookah at least once per week for > 20 years.
- 35-49 y/o cigarette smokers: have > 20 pack-year cigarette smoking history.
- All subjects must have:
- no history of illicit drug use or marijuana.
- no evidence of cardiopulmonary disease by history or physical.
- no diabetes with fasting blood glucose <100 mg/dl.
- BP<140/90 mmHg.
- resting heart rate<100 bpm.
- BMI<30kg•m2.
- no prescription medication.
- normal EKG and echocardiogram.
You may not qualify if…
- suboptimal echocardiographic window.
- exhaled CO>10 ppm (smoking non-abstinence).
- positive pregnancy test.
- psychiatric illness.
- other conditions deemed unsafe to participate.
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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