Metabolism of Ornithine Phenylacetate

Completed · Not applicable

Conditions studied: Healthy

In brief

Intravenous infusion of stable tracers of ornithine, glutamine, glutamate, and glycine will be performed, and collect blood samples, urine samples, and muscle biopsies to evaluate the effect of a continuous oral intake of phenylacetate salt of ornithine (OP) on its metabolic fate.

Key facts

Study ID

NCT03159390

Run by

Texas A&M University

People needed

20

Starts

2015-02-03

Expected to finish

2015-04-30

Last updated by the study team

2025-09-30

Who can join

Age: 40 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Metabolic diseases including diabetes and hepatic or renal disorders
• Presence of acute illness or metabolically unstable chronic illness
• Failure to give informed consent
• (Possible) pregnancy
• Any other condition according to the PI or nurse that would interfere with the study or safety of the patient or influence the results
• Unwilling to stop taking nutritional protein supplements within 5 days before test day
• History of hypo- or hyper-coagulation disorders, including use of a Coumadin derivative, history of deep venous thrombosis (DVT), or pulmonary embolism (PE) at any point in lifetime
• Currently taking anti-thrombotics (i.e. medical indication) and cannot stop for 3-7 days prior to test days
• Allergy to local anesthetic

Where it is running

• Texas A&M University-CTRAL — College Station, Texas, United States

Full record on ClinicalTrials.gov

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