Parkinson's Autonomic Responses to Treadmill Walking

Completed · Not applicable

Conditions studied: Parkinson Disease, Autonomic Dysfunction

In brief

This study will compare examine autonomic and cardiovascular responses to peak exercise testing in Parkinson's disease patients in varying stages of the disease, and healthy, age-matched participants. Participants will be asked to complete a peak exercise test on a motorized treadmill. Heart rate, blood pressure, norepinephrine, and other markers for cardiovascular function will be assessed at rest, during exercise, and post-exercise. The hypothesis to be tested is that Parkinson's disease patients will exhibit a decreased autonomic and cardiovascular response to exercise when compared to patients' healthy age-matched counterparts. The investigators secondary hypothesis is that Parkinson's disease patients in more advanced stages will exhibit a greater decrease in response when compared to these patients' Stage 1 counterparts, or healthy age-matched counterparts.

Key facts

Study ID

NCT03156400

Run by

University of Miami

People needed

30

Starts

2017-02-15

Expected to finish

2018-06-01

Last updated by the study team

2018-07-06

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women can be included in the study if these potential participants are between 50 and 85 years of age and meet the following criteria:
• Have received clearance from a primary physician to perform a peak exercise test.
• Will be able to walk on a motorized treadmill with supporting harness system.
• Are Individuals with PD having recently had a diagnosis of Stage 1, or 2, or 3 on the Hoehn and Yahr scale and can present the research team with evidence from the potential participant's physician stating the diagnosis.
• Or,
• The potential participant is a healthy individual with no unresolved cardiovascular, neuromuscular, and/or musculoskeletal disease.

You may not qualify if…

• Men and women will be excluded from participation if the individual:
• Has been advised by a physician not to exercise.
• Is currently participating, or within the past 3 months has participated, in an exercise training program.
• Is currently on any cardiac or blood pressure medication.
• Has any additional neurological disorder.
• Is considered to be at high risk for cardiovascular disease as determined by the - American College of Sports Medicine (ACSM) risk stratification screening questionnaire or their primary physician.
• Is unable to provide informed consent.
• has a Mini-mental score less than 18.
• Is pregnant.
• Is currently a prisoner.

Where it is running

• Laboratory of Clinical Research — Coral Gables, Florida, United States

Full record on ClinicalTrials.gov

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