Novel Biomarkers and Echocardiography for Subclinical Cardiac Toxicity in Breast Cancer Patients Receiving Anthracyclines
Status unconfirmed
Conditions studied: Cardiotoxicity, Heart Failure, Breast Cancer, Anthracycline Induced Cardiomyopathy, Biomarkers, Echocardiography
In brief
This is a pilot prospective cohort study, in adult female subjects 18-85 years old with a diagnosis of invasive breast cancer who are planned for anthracycline-inclusive chemotherapy and followed up for a time period of 6 months post completion of anthracycline chemotherapy. They will participate in blood and imaging tests with a goal of determining the best method for predicting the occurrence of cardiotoxicity in this subpopulation.
Key facts
- Study ID
- NCT03155802
- Run by
- Stony Brook University
- People needed
- 35
- Starts
- 2017-04-18
- Expected to finish
- 2020-12-01
- Last updated by the study team
- 2019-11-01
Who can join
Age: 18 and older, up to 85. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Female subjects aged 18-85 years old
- Biopsy-proven diagnosis of invasive breast cancer carcinoma
- Plan for anthracycline inclusive chemotherapy (+/- taxanes, +/- trastuzumab)
You may not qualify if…
- History of major heart disease at the time of breast cancer diagnosis (myocardial infarction or known left ventricular dysfunction (LVD) at baseline (defined as ejection fraction <40%)
- History of known obstructive coronary artery disease (CAD), or coronary revascularization within the past 1 year
- History of clinical heart failure or previous heart failure hospitalization
- Patients with elevations in NT-pro BNP (above 3x ULN), or ST2 (above 2x ULN), galectin-3 (above 2x ULN), or hs troponin (above 2x ULN) during baseline screening
- Patients with metastatic disease or recurrent breast cancer at diagnosis
- History of other chemotherapy treated malignancy
Where it is running
- Stony Brook Medicine — Stony Brook, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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