Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy

Completed · Phase 1

Conditions studied: Acute Mountain Sickness

In brief

This double blind randomized trial will compare ibuprofen to acetazolamide for the prevention of acute mountain sickness. These drugs have never been directly compared for efficacy. The study population is hikers who are ascending at their own rate under their own power in a true hiking environment at the White Mountain Research Station, Owen Valley Lab (OVL) and Bancroft Station (BAR), Bancroft Peak, White Mountain, California.

Key facts

Study ID

NCT03154645

Run by

Grant S Lipman

People needed

92

Starts

2017-08-12

Expected to finish

2017-10-01

Last updated by the study team

2018-11-26

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-65 healthy non-pregnant volunteer
• Sea-level dwelling (live at low elevation < 4000 ft)
• Arrange your own transportation to WMRS (Bishop) by Friday evening of study weekend
• Available for full study duration (Friday PM-Sunday AM)

You may not qualify if…

• Age <18 or >65, Pregnant, Live at altitude >4000 ft
• Slept at altitude > 4000ft within 1 week of study
• Allergic to acetazolamide, sulfa drugs, or non-steroidal anti-inflammatories
• Taking NSAIDs, Acetazolamide, or Corticosteroids 1 week prior to study
• Medical History of Brain Tumor, increased brain pressure, pseudotumor cerebri, VP shunts, HACE, or HAPE.

Where it is running

• White Mountain Research Station — Bishop, California, United States

Full record on ClinicalTrials.gov

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