Effects of Stress and Drug-cue Exposure (SCM)

Completed · Phase 1

Conditions studied: Marijuana Abuse

In brief

The purpose of the proposed study to examine the links among stress, craving for marijuana, and marijuana reminders, or "cues". In this study, an agent called yohimbine will be used to produce stress-like responses. Yohimbine is known to cause stress response in studies of alcohol and other substance use disorders. This study intends to show it can be used to cause stress in marijuana users as well.

Key facts

Study ID

NCT03154567

Run by

Wayne State University

People needed

12

Starts

2017-11-01

Expected to finish

2023-10-27

Last updated by the study team

2024-04-23

Who can join

Age: 21 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants (18-55 yr) will be current marijuana users, based on self-report and THC-positive urine samples.
• Candidates must meet DSM-5 criteria for Mild-to-Moderate Cannabis Use Disorder (CUD) and be willing to participate in research but not seeking treatment.
• Candidates must be in good health, as assessed using data from psychiatric evaluation, extensive substance use history interview, and medical evaluations including medical history, physical exam, standard lab tests and 12-lead ECG.

You may not qualify if…

• Candidates with the following conditions will be excluded:
• Serious psychiatric illness (e.g. psychotic or bipolar disorder, recent suicide attempts, major depression).
• Substance Use Disorders other than Cannabis or Nicotine Use Disorders and Mild Alcohol Use Disorder.
• Neurological diseases
• Cardiovascular problems (e.g. including systolic BP >140 or <95 mmHg, diastolic BP >90 mmHg, abnormal ECG).
• Pulmonary diseases
• Systemic diseases
• Cognitive impairment (<80 IQ)
• Past-month medications that increase study risk.
• Women who are pregnant, lactating, or if heterosexually active and not using medically approved birth control.
• Candidates seeking Substance Use Disorder treatment.
• Individuals unable to give voluntary informed consent will be excluded.

Where it is running

• Tolan Park Medical Building — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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