Safety and Efficacy of Diacerein 1% Ointment for Subjects With Epidermolysis Bullosa Simplex (EBS)
Stopped early · Phase 2 · Has a placebo group
Conditions studied: Epidermolysis Bullosa Simplex
In brief
Epidermolysis bullosa simplex (EBS) is a rare genetic skin disease characterized by fragility of the skin and mucous membranes resulting in painful blisters and erosions after minor trauma. The purpose of this study is to compare the efficacy of diacerein 1% ointment to vehicle ointment when applied once-daily for 8 weeks in subjects with EBS.
Key facts
- Study ID
- NCT03154333
- Run by
- Castle Creek Pharmaceuticals, LLC
- People needed
- 54
- Starts
- 2017-06-01
- Expected to finish
- 2018-10-31
- Last updated by the study team
- 2019-11-05
Who can join
Age: 4 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Phoenix Childrens Hospital — Phoenix, Arizona, United States
- Stanford University — Palo Alto, California, United States
- Children's Hospital Colorado — Aurora, Colorado, United States
- Ann and Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
- Northwestern University — Chicago, Illinois, United States
- University of Minnesota — Minneapolis, Minnesota, United States
- University of Missouri Healthcare — Columbia, Missouri, United States
- Stony Brook University Medical Center — Stony Brook, New York, United States
- University of North Carolina - Chapel Hill — Chapel Hill, North Carolina, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- Medical University of South Carolina (MUSC) — Charleston, South Carolina, United States
- Children's Hospital of San Antonio ; Texas Dermatology and Laser Specialists — San Antonio, Texas, United States
- Premier Specialists Pty Ltd; The Church — Kogarah, New South Wales, Australia
- EB House Austria — Salzburg, Austria
- Hopital Saint Louis — Paris, Cedex, France
- Hopital Necker-Enfants Malades — Paris, Cedex, France
- CHU de NICE - Hopital de l'Archet II - Service de Dermatologie — Nice, France
- University Medical Center Freiburg — Freiburg im Breisgau, Germany
- Tel Aviv Sourasky Medical Center — Tel Aviv, Israel
- University Medical Center Groningen — Groningen, Netherlands
- Great Ormond Street Hospital — London, England, United Kingdom
- St. Thomas' Hospital - St Johns Institute of Dermatology — London, United Kingdom
Full record on ClinicalTrials.gov
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