Predictors of Response to Treatment for Depression

Completed · Not applicable

Conditions studied: Adolescent Depression, Depression

In brief

The current study will examine neurophysiological, specifically event-related potential (ERP), measures of emotional processing as predictors of response to cognitive behavior therapy for adolescent depression.

Key facts

Study ID

NCT03154008

Run by

Vanderbilt University Medical Center

People needed

70

Starts

2017-06-01

Expected to finish

2020-06-08

Last updated by the study team

2020-07-23

Who can join

Age: 14 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants presenting with major depressive or persistent depressive disorder and moderate severity on the Clinical Global Impressions scale.
• Participants may have comorbid externalizing or anxiety disorders.
• Participants (and parents of minors) fluent in English.

You may not qualify if…

• Youth with history of treatment for substance use disorders.
• Youth with intellectual or developmental disabilities (e.g., autism spectrum disorders, pervasive developmental disorders).
• Youth with lifetime schizophrenia, psychosis, or mania.
• Youth with severe current suicidality.
• Youth taking antipsychotic medications or mood stabilizers.
• Youth with recent changes in dosage of antidepressant (adolescents with change in dosage in past 30 days who otherwise meet study criteria will be asked to begin the study once dosage has been stable for 30 days).
• Parent or child not fluent in English.
• Youth who are unable to complete study procedures because of visual or hearing impairments.
• Youth who have recently started outside therapy (past 30 days at time of intake), are engaged in treatment that is determined to be too similar to study therapy (e.g, other CBT groups), or are currently in treatment that is too intensive to allow for participation in study therapy (e.g., partial hospitalization programs)

Where it is running

• Vanderbilt University — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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