Sedentary Behavior and Health Outcomes Study
Completed · Not applicable
Conditions studied: Sedentary Lifestyle, Metabolic Disturbance, Pediatric Obesity, Physical Activity
In brief
This study is a randomized crossover trial to compare the effectiveness of interrupting SB on glucose homeostasis in the lab and free-living settings. All participants (N=56) will complete one screening visit to determine eligibility, complete at fitness test, and body composition analysis by bioelectrical impedance. After 7-21 days, all participants will complete two 3-hour in-lab oral glucose tolerance tests (spaced 7-21 days apart). Prior to the in-lab OGTT visits, participants will wear an activity monitor for 7 days on the right thigh. The experimental conditions for the OGTTs will be: 1) 3-hour OGTT of continuous sitting; and 2) 3-hour OGTT with sitting interrupted every 30 minutes with 3-minutes of moderate intensity walking on a treadmill. There will be a 7-21 day washout period between the OGTT visits. In addition, a subset of participants (N=12) who meet inclusion criteria and who successfully complete both OGTT visits will complete a second randomized crossover trial in the free-living environment. The experimental conditions for the free-living components will be: 1) 4 days of habitual sedentary behaviors; and 2) 4 days of prompted short exercise breaks during times in which sedentary behaviors have exceeded 30 minutes. Participants in the free-living trial will wear an activity monitor and a continuous glucose monitor.
Key facts
- Study ID
- NCT03153930
- Run by
- University of Southern California
- People needed
- 35
- Starts
- 2018-01-01
- Expected to finish
- 2020-06-30
- Last updated by the study team
- 2020-11-13
Who can join
Age: 11 and older, up to 16. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- current/past participant in the MATCH Study
- good general health
- fasting plasma glucose <100 mg/dL
- BMI greater than the 5th percentile
You may not qualify if…
- significant cardiac or pulmonary disease likely to or resulting in hypoxia or decreased perfusion
- evidence of impaired glucose tolerance or type 2 diabetes
- presence of other endocrinologic disorders leading to obesity (e.g.: Cushing Syndrome)
- current or past anti-psychotic drugs use that would affect metabolism
- non-diet treatment for hypertension or dyslipidemia
- precocious puberty and/or receiving androgen and estrogen therapy
- medication use known to affect body composition/weight
Where it is running
- University of Southern California Keck School of Medicine — Los Angeles, California, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.