Assessment of Duodenal Epithelial Integrity in Celiac Disease With Mucosal Impedance

Completed

Conditions studied: Celiac Disease

In brief

Increased intestinal permeability can represent compromise of the epithelium's integrity and is thought to be the primary mechanism in patients who develop Celiac Disease (CeD) and non-celiac gluten sensitivity when gluten peptides cross the barrier and trigger an immune response. In this study, the investigators propose to use a novel, minimally invasive technology to detect mucosal damage (i.e. barrier dysfunction) in the duodenal epithelium. The primary aim of this study is to identify if there is a difference in duodenal mucosal impedance between CeD and control patients.

Key facts

Study ID

NCT03152279

Run by

Vanderbilt University Medical Center

People needed

33

Starts

2016-12-01

Expected to finish

2018-11-14

Last updated by the study team

2021-05-06

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• scheduled for endoscopy as part of routine care with or without suspected Celiac Disease based upon at least 1 positive serologic marker of CeD
• consuming gluten at time of endoscopy

You may not qualify if…

• Already on a gluten free diet or unwilling to undergo a gluten challenge
• Undergoing upper endoscopy for an urgent indication such as unstable gastrointestinal bleed or food impaction
• Patients with inflammatory bowel disease
• Patients on blood thinners other than aspirin at time of endoscopy
• Patient unable to give informed consent
• Patient less than 18 years old

Where it is running

• Vanderbilt University Medical Center Endoscopy Laboratory — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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