Study to Assess Safety, Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Participants With Locally Advanced or Metastatic Solid Tumors
Completed · Phase 1
Conditions studied: Locally Advanced or Metastatic Solid Tumors
In brief
The primary objective of this study was to determine the safety and tolerability of pamiparib, the maximum tolerated dose (MTD) or maximum administered dose (MAD) for pamiparib combined with TMZ, to select the recommended Phase 2 dose (RP2D) and schedule of pamiparib in combination with TMZ, and to determine the antitumor activity of pamiparib in combination with TMZ.
Key facts
- Study ID
- NCT03150810
- Run by
- BeiGene
- People needed
- 139
- Starts
- 2017-06-28
- Expected to finish
- 2023-05-04
- Last updated by the study team
- 2024-12-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Start Midwest — Grand Rapids, Michigan, United States
- Washington University in St Louis — St Louis, Missouri, United States
- Mount Sinai Prime — New York, New York, United States
- Montefiore Medical Park At Eastchester Einstein Campus — The Bronx, New York, United States
- Sarah Cannon Cancer Center — Nashville, Tennessee, United States
- Texas Oncology (Loop) Usor — Dallas, Texas, United States
- The University of Texas Md Anderson Cancer Center — Houston, Texas, United States
- Chris Obrien Lifehouse — Camperdown, New South Wales, Australia
- Saint Vincents Hospital Sydney — Darlinghurst, New South Wales, Australia
- Icon Cancer Centre South Brisbane — South Brisbane, Queensland, Australia
- Peter Maccallum Cancer Centre — Melbourne, Victoria, Australia
- Hospital Universitario Vall Dhebron — Barcelona, Spain
- Ico H Duran I Reynals — Barcelona, Spain
- Hospital Universitario Ramon Y Cajal — Madrid, Spain
- Start Madrid Fundacion Jimenez Diaz — Madrid, Spain
- Centro Integral Oncologico Clara Campal — Madrid, Spain
- Hospital Universitario Virgen de La Macarena — Seville, Spain
- Hospital Clinico Universitario de Valencia — Valencia, Spain
- Beatson West of Scotland Cancer Centre — Glasgow, United Kingdom
- Northern Centre For Cancer Care — High Heaton, United Kingdom
- University College Hospital — London, United Kingdom
- Sarah Cannon Research Institute Uk — London, United Kingdom
Full record on ClinicalTrials.gov
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