Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury

Recruiting now · Phase 2

Conditions studied: Peripheral Nerve Injuries

In brief

The aim of this clinical trial is to evaluate the efficacy of tesamorelin as a therapy for peripheral nerve injuries. The investigators hypothesize that treatment with tesamorelin will result in faster and more substantial recovery of motor and sensory function following surgical repair of injured peripheral nerves. Patients with upper extremity nerve injuries will be randomly assigned to receive either tesamorelin treatment or no treatment. Assessments for nerve regeneration, muscle function, and sensation will be conducted every three months for a total of 12 months. Outcomes in patients receiving tesamorelin will be compared to those in the untreated group to determine the effectiveness of tesamorelin as a therapeutic intervention for nerve injuries.

Key facts

Study ID

NCT03150511

Run by

Johns Hopkins University

People needed

36

Starts

2018-06-01

Expected to finish

2027-12-01

Last updated by the study team

2025-11-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ulnar nerve laceration at the wrist, repaired primarily

You may not qualify if…

• Certain cancers (active or in the past)
• Uncontrolled diabetes or hypertension
• Certain pituitary problems
• Oral contraceptives
• Pregnancy
• Drug or alcohol dependence
• Psychosocial issues that would limit participation and compliance

Where it is running

• Sami Tuffaha — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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