High-Flow Nasal Cannula and Desaturation Episodes in the Morbidly Obese Patients
Completed · Not applicable
Conditions studied: Desaturation of Blood, Obesity, Colonoscopy, Sleep Apnea, High Flow Nasal Cannula
In brief
It is standard practice in the United States and many parts of world to perform Gastrointestinal (GI) endoscopy with the patient under deep sedation. Obesity is accepted as a patient specific risk factor for hypoxic events during procedural sedation for GI endoscopic procedures. The Obese population has a higher prevalence of obstructive sleep apnea (OSA) which is characterized by repeated obstruction of the upper airway, and leads to apnea and desaturation. This prospective, randomized study was designed to compare the effectiveness of the high flow nasal cannula and the standard nasal cannula in morbidly obese (BMI \> 40) patients receiving deep intravenous sedation during colonoscopies. This study will assess whether use of the high flow nasal cannula (HFNC) leads to less intraoperative desaturation events compared to the current standard of care.
Key facts
- Study ID
- NCT03148262
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 59
- Starts
- 2017-05-10
- Expected to finish
- 2018-01-22
- Last updated by the study team
- 2018-11-19
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age between 18-80
- Subjects undergoing colonoscopies
- Morbidly obese BMI ≥ 40
You may not qualify if…
- Subjects deemed hemodynamically unstable by the anesthesia team
- Subjects who are an aspiration risk and will require endotracheal intubation.
- Pregnancy
- Subjects with an allergy to propofol
- Patients who are unable to tolerate the high flow nasal cannula secondary to discomfort
- Subjects unwilling to sign consent
- Chronic obstructive pulmonary disease
- Patients that received medications other than lidocaine and propofol
Where it is running
- Parkland Helath Hospital System — Dallas, Texas, United States
- Parkland Hospital — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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