A Biomarker to Detect Salt Sensitivity

Completed

Conditions studied: Hypertension Uncomplicated, Pre Hypertension

In brief

The investigators are proposing that individuals with elevated levels of NT-proBNP are resistant to natriuretic peptides and are unable to handle sodium loads and maintain optimal blood pressure values.The investigators will test this hypothesis by comparing the blood pressure response to low and high salt diets in individuals with pre- or hypertension and who have normal or elevated levels of NT-proBNP. The investigators expect that blood pressure values in those with normal levels of NT-proBNP will not change with high salt diets, whereas, in those with elevated levels of NT-proBNP, blood pressure values will increase significantly when exposed to high salt diets.

Key facts

Study ID

NCT03147170

Run by

University of Minnesota

People needed

30

Starts

2016-01-01

Expected to finish

2018-12-31

Last updated by the study team

2019-04-18

Who can join

Age: 30 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Systolic blood pressure > 120 and < 160 mmHg
• Diastolic blood pressure > 80 and < 100 mmHg
• Not on hypertensive medications
• NT-proBNP between 40 - 99 pg/mL (healthy levels)
• NT-proBNP > 120 pg/mL (elevated levels)

You may not qualify if…

• Physician reported diabetes or on insulin or oral hypoglycemic agents
• BMI > 40kg/m2
• Age < 30 or > 75 years
• Presence of cardiovascular disease or chronic kidney disease
• Chronic obstructive pulmonary disease or pulmonary arterial hypertension
• Aldosterone secreting disorder
• Estimated energy intake greater than 3400 calories
• Pregnancy
• Individuals with pacemakers

Where it is running

• University of Minnesota Medical Center — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.