Exercise and Asthma in Obese Adults

Completed · Not applicable

Conditions studied: Asthma in Overweight Adults

In brief

This pilot study will use an unmasked, parallel group, randomized design. Thirty adult overweight or obese subjects with mild-moderate persistent asthma will be randomly assigned to one of two groups: 12-weeks of home-based moderate intensity aerobic exercise versus no intervention. The study will include 2 clinic visits and 12 telephone calls. Exercise testing to assess physical fitness levels will occur during visits 1 and 2. Blood sampling for biomarkers, inflammatory markers, and other assessments will be done.

Key facts

Study ID

NCT03145883

Run by

University of Arizona

People needed

30

Starts

2015-07-01

Expected to finish

2017-09-01

Last updated by the study team

2017-10-16

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Physician diagnosed asthma
• Currently prescribed a daily controller asthma medication as evidence of mild-moderate persistent asthma
• Body Mass Index BMI ≥ 30-45 kg/m2

You may not qualify if…

• Individuals who undergo aerobic exercise regularly (3 or more times per week for more than 20 minutes) 6 months prior to the study
• Participants with very severe obesity (WHO obese class III) - BMI≥ 45 kg/m2
• Individuals with other clinically significant major illnesses, such as congenital heart disease, juvenile arthritis, inflammatory bowel disease, cystic fibrosis, or other conditions that would limit participation in the exercise protocol or interfere with study measurements will not be eligible.
• Uncontrolled hypertension (resting systolic blood pressure > 150mmHg, and/or diastolic blood pressure >90 mmHg despite anti-hypertension medications.
• Current use of beta blockers
• Currently pregnant, pregnant during the previous six months, or planning to become pregnant in the next three months as obtained by self-report.
• Participants who have experienced a clinically significant exacerbation within the past 6 weeks will be excluded. This includes an unscheduled physician visit, emergency room visit, or hospitalization related or use of systemic corticosteroids for asthma.
• Unable or unwilling to provide consent
• Unable or unwilling to perform the exercise protocol and provide study measurements,
• Inability to perform baseline measurements
• Intend to move out of the area within 3 months from the start of the study
• Inability to be contacted by telephone

Where it is running

• The University of Arizona and the Tucson Unified School District — Tucson, Arizona, United States

Full record on ClinicalTrials.gov

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