Expanded Access Protocol Using Alpha/Beta T and CD19+ Depleted PBSC

Available (expanded access)

Conditions studied: Leukemia, Bone Marrow Failure Syndrome, Immunodeficiencies

In brief

The primary objective of this protocol is to expand access for patients who lack a fully HLA (Human leukocyte antigen) matched sibling donor, and who are candidates for allogeneic hematopoietic stem cell transplant (HSCT). These patients have a serious or immediately life-threatening disease for which HSCT is indicated. These patients are not eligible for other Children's Hospital of Philadelphia Institutional Review Board (IRB) approved protocols that utilize CliniMACs technology for T depletion.

Key facts

Study ID
NCT03145545
Run by
Children's Hospital of Philadelphia
Last updated by the study team
2026-07-08

Who can join

Age: 0 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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