The Acute Burn Resuscitation Multicenter Prospective Observational Trial

Completed

Conditions studied: Burns, Shock

In brief

This is a prospective, non-interventional, observational study of consecutive burn patients admitted to 20 selected burn centers in North America. Primarily, data collection will be continuous "real-time" documentation of fluid infusion rates, vital signs and laboratory values of patients receiving fluid resuscitation during the first 48 hours following burn injury. All aspects of the resuscitation and all investigations performed will be according to the participating center's regular protocol, as this is purely an observational and non-interventional study. Further data collection on outcomes (organ function, ventilation duration, length of stay, and survival) will be collected at 72h, 96 h, and at hospital discharge.

Key facts

Study ID

NCT03144427

Run by

American Burn Association

People needed

400

Starts

2017-02-24

Expected to finish

2021-07-15

Last updated by the study team

2021-07-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• ≥ 20% TBSA burns
• Admitted to the burn center ≤ 12 post injury

You may not qualify if…

• Significant associated trauma
• High voltage (≥ 1000 volts) electrical burns
• Surgery anticipated within 48 hours from injury
• Fresh frozen plasma (FFP) anticipated to be given at any time ≤ 48 hours from injury
• Hypertonic saline (HTS) anticipated to be given at any time ≤ 48 hours from injury
• Hydroxyethyl starch (HES) anticipated to be given at any time ≤ 48 hours from injury
• High dose Vitamin C infusion is anticipated to be given at any time ≤ 48 hours from injury
• Death occurs or comfort measures are instituted within ≤ 48 hours from injury

Where it is running

• University of California Davis Medical Center-Regional Burn Center — Sacramento, California, United States

Full record on ClinicalTrials.gov

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