Blood Flow Restriction to Improve Muscle Strength After ACL Injury
Completed · Not applicable
Conditions studied: Anterior Cruciate Ligament Injury
In brief
Quadriceps muscle weakness is a common consequence following anterior cruciate ligament (ACL) injury and reconstruction. Maximizing quadriceps strength following ACL injury is significant as diminished quadriceps strength has been linked to the osteoarthritis that affects over 50% of surgically reconstructed limbs. Given that knee joint health following ACL injury is predicated on restoring quadriceps strength, identifying treatment approaches capable of improving strength is paramount. Blood flow restriction training (BFRT) is a method where oxygen to the muscle is intentionally reduced during exercise/rehabilitation and may lead to more timely and substantial strength gains. In the proposed project, we will examine the efficacy of BFRT in patients who have undergone ACL reconstruction and suffer from substantial quadriceps weakness.
Key facts
- Study ID
- NCT03141801
- Run by
- University of Michigan
- People needed
- 48
- Starts
- 2016-08-25
- Expected to finish
- 2018-11-21
- Last updated by the study team
- 2019-01-23
Who can join
Age: 14 and older, up to 30. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- suffered an acute, complete ACL rupture as confirmed by MRI
- scheduled to undergo ACL reconstruction
- scheduled to undergo ACL reconstruction with a surgeon affiliated with MedSport (University of Michigan Orthopaedic Clinic)
- willing to undergo rehabilitation through MedSport (University of Michigan Orthopaedic Clinic) 5)) Willingness to participate in testing and follow-up as outlined in the protocol
- English-speaking
You may not qualify if…
- inability to provide written informed consent (or assent)
- female subjects who are pregnant or are planning to become pregnant during the study timeframe
- previous ACL injury
- previous surgery to either knee
- bony fracture accompanying ACL injury
- chronic ACL injuries (for our study, this is defined as patient reporting to a physician greater than 2 weeks after initial injury)
- patients who experienced a knee dislocation
- History of blood clots
- Previous deep vein thrombosis
- Use of estrogen or progestin contraceptive
- History of cerebrovascular disease
- History of peripheral vascular disease
- History of Sickle Cell Anemia
- History of chronic muscular disorder (e.g. fibromyalgia)
- History of severe hypertension
Where it is running
- University of Michigan — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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