Mupirocin-Iodophor ICU Decolonization Swap Out Trial

Completed · Phase 4

Conditions studied: Staphylococcus Aureus

In brief

The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the non-inferiority of two decolonization regimens: Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in the context of chlorhexidine for daily bathing; Arm 2 Intervention: ICU nasal decolonization with iodophor twice daily for 5 days in the context of chlorhexidine for daily bathing Note: that enrolled "subjects" represents 137 individual HCA Hospitals (representing \~235 ICUs) that have been randomized.

Key facts

Study ID

NCT03140423

Run by

Harvard Pilgrim Health Care

People needed

353323

Starts

2017-05-01

Expected to finish

2023-11-06

Last updated by the study team

2025-03-30

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inclusion criteria includes all U.S. HCA hospitals with an adult ICU;
• Note: Unit of randomization is the hospital, but the participants are hospital adult ICUs
• All patients within adult ICUs are included, including rare patients <18 years and >=12 years.

You may not qualify if…

• Exclusion criteria includes ICUs with an average length of stay of less than 2 days;
• HCA hospitals that are not able to transfer or merge data into the centralized data warehouse for the baseline and intervention periods of the study are also excluded.

Where it is running

• Regional Medical Center of San Jose — San Jose, California, United States
• Good Samaritan Hospital — San Jose, California, United States
• Los Robles Regional Medical Center — Thousand Oaks, California, United States
• West Hills Hospital & Medical Center — West Hills, California, United States
• The Medical Center of Aurora — Aurora, Colorado, United States
• Swedish Medical Center — Denver, Colorado, United States
• Sky Ridge Medical Center — Denver, Colorado, United States
• Presbyterian St. Luke's Medical Center — Denver, Colorado, United States
• Rose Medical Center — Denver, Colorado, United States
• North Suburban Medical Center - JV — Thornton, Colorado, United States
• JFK Medical Center — Atlantis, Florida, United States
• Aventura Hospital — Aventura, Florida, United States
• Blake Medical Center — Bradenton, Florida, United States
• Brandon Regional — Brandon, Florida, United States
• Oak Hill Hospital — Brooksville, Florida, United States
• Englewood Community Hospital — Englewood, Florida, United States
• Fort Walton Medical Center — Fort Walton Beach, Florida, United States
• Lawnwood Regional Medical Center — Ft. Pierce, Florida, United States
• North Florida Regional Medical Center — Gainesville, Florida, United States
• Regional Medical Center Bayonet Point — Hudson, Florida, United States
• Memorial Hospital Jacksonville — Jacksonville, Florida, United States
• Osceola Regional Medical Center — Kissimmee, Florida, United States
• Poinciana Medical Center — Kissimmee, Florida, United States
• Lake City Medical Center — Lake City, Florida, United States
• Riverside Community Hospital — Riverside, California, United States

Full record on ClinicalTrials.gov

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