Metoprolol to Reduce Perioperative Myocardial Injury

Completed · Phase 3 · Has a placebo group

Conditions studied: Heart Diseases

In brief

The purpose of this research study is to test if a commonly used, FDA-approved medication, called metoprolol, given at the conclusion of anesthesia following surgery, and during postoperative admission, reduces the possibility of heart related complications in patients with coronary artery disease (CAD).

Key facts

Study ID

NCT03138603

Run by

University of Chicago

People needed

72

Starts

2016-12-01

Expected to finish

2023-08-29

Last updated by the study team

2026-01-28

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >= 50 years
• Beta-blocker naïve [30 days prior to surgery]
• Previously diagnosed coronary artery disease (CAD), or
• History of peripheral vascular disease (PVD), or
• Chronic kidney disease (CKD) [eGFR ≤60ml/min], or
• History of positive stress test or
• At high risk for CAD (must meet at least 2 criteria):
• i. Age >= 70 years ii. Hypertension iii. Diabetes requiring oral medication or insulin iv. Current smoker or some days smoker within the past 2 years
• Major non-cardiac, elective surgery under general anesthesia

You may not qualify if…

• Subjects will not be enrolled if any of the following criteria exist:
• History of stroke, or transient ischemic attack (TIA)
• Previously diagnosed carotid disease, i.e., either 70% unilateral or 50% bilateral carotid occlusion.
• Heart rate <=55bpm
• Congestive heart failure with New York Heart Association(NYHA) Functional Classification of III-IV or left ventricular heart failure with ejection fraction ≤50%
• Severe valvular regurgitation
• Second or third degree atrioventricular (AV) block without pacemaker
• Active asthma or chronic obstructive pulmonary disease (COPD) with symptoms or resolving symptoms on day of surgery
• Anemia [HB<=9g/dL]
• Allergy to beta-blockade drugs
• Unwilling or unable to give consent for participation
• Undergoing any carotid endarterectomy, endovascular, endoscopic, superficial, or ambulatory procedures
• Pregnancy or lactating women
• Prisoners

Where it is running

• University of Chicago Medicine — Chicago, Illinois, United States
• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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