Lidocaine vs Ketorolac for Management of Renal Colic in the Emergency Department

Status unconfirmed · Phase 4 · Has a placebo group

Conditions studied: Renal Colic

In brief

The hypothesis of the study is that lidocaine will be as effective as ketorolac in decreasing patient's perception of pain as measured by the 10 point Visual Analogue Scale (VAS). The aim of the study is to compare the safety \& efficacy of lidocaine versus ketorolac for acute pain secondary to renal colic in the Emergency Department (ED).

Key facts

Study ID

NCT03137498

Run by

The Brooklyn Hospital Center

People needed

60

Starts

2017-03-06

Expected to finish

2019-03-06

Last updated by the study team

2018-07-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients 18 years old and older
• Presenting with acute generalized pain secondary to suspected or confirmed renal colic
• Describes pain to be greater than or equal to 3 out of 10 on the numeric rating scale (NRS)
• Provides informed consent.

You may not qualify if…

• Reported/documented allergy to lidocaine OR ketorolac (Toradol) OR morphine, corn, aspirin, ibuprofen
• Patients who are hemodynamically unstable as dictated by the medical resident or attending [(Heart rate not within 60-110bpm); (Respiratory rate not within 12-20 bpm); (Blood pressure not within 90/50 to 180/100); (Oxygen saturation not within 94-100%)]
• Patient with unwillingness to provide informed consent
• Patients with past medical history of cardiovascular disorders (examples include but are not limited to: myocardial infarction, ischemic heart disease, atrial fibrillation, heart blocks, Wolff-Parkinson-White syndrome, slow heart rate, bradycardia, coronary artery disease, QT prolongation)
• Past medical history of: liver dysfunction (ie: cirrhosis), chronic alcohol abuse, gastrointestinal bleed or recent gastrointestinal bleed (within past 5 days), renal dysfunction or disease, seizures (or currently actively receiving treatment for seizures), inflammatory bowel disease (or currently actively receiving treatment for inflammatory bowel disease), hepatitis (or currently actively receiving treatment for hepatitis).
• History of liver transplant
• Currently on dialysis
• Has acute heart, kidney, liver, respiratory failure or trauma
• In altered mental status
• In significant trauma, actively breastfeeding or pregnant
• Has language barriers who are unable to describe pain,
• Weighing at or over 130kg
• Has a blood pressure reading greater than 180/120 mmHg at triage,
• Previously enrolled to the study

Where it is running

• The Brooklyn Hospital Center — Brooklyn, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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