A Study of Obinutuzumab in Combination With Idasanutlin and Venetoclax in Participants With Relapsed or Refractory (R/R) Follicular Lymphoma (FL) or Rituximab in Combination With Idasanutlin and Venetoclax in Participants With R/R Diffuse Large B-Cell Lymphoma (DLBCL)

Stopped early · Phase 1/Phase 2

Conditions studied: Follicular Lymphoma, Lymphoma, Large B-Cell, Diffuse

In brief

This Phase Ib/II, open-label, multicenter, non-randomized, dose-escalation study will evaluate the safety, efficacy, and pharmacokinetics of obinutuzumab in combination with idasanutlin and venetoclax in participants with R/R FL and obinutuzumab or rituximab in combination with idasanutlin and venetoclax in participants with R/R DLBCL. The study will include an initial dose-escalation phase followed by an expansion phase. The dose-escalation phase is designed to determine the recommended phase II doses (RP2Ds) and regimen for idasanutlin and venetoclax in combination with obinutuzumab for FL participants and in combination with rituximab for DLBCL participants.

Key facts

Study ID

NCT03135262

Run by

Hoffmann-La Roche

People needed

29

Starts

2017-06-15

Expected to finish

2020-04-30

Last updated by the study team

2021-12-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
• B-cell lymphoma classified as either of the following: R/R FL after treatment with at least one prior chemoimmunotherapy regimen that included an anti-cluster of differentiation 20 (CD20) monoclonal antibody; R/R DLBCL after treatment with at least one prior chemoimmunotherapy regimen that included an anti-CD20 monoclonal antibody in participants who are not eligible for second line combination chemotherapy and autologous stem-cell transplantation, have failed second line combination chemotherapy, or experienced disease progression following autologous stem-cell transplantation
• Histologically documented CD20-positive lymphoma
• Fluorodeoxyglucose (FDG)-avid lymphoma (that is [i.e.], PET-positive lymphoma)
• At least one bi-dimensionally measurable lesion (greater than [>] 1.5 centimeters [cm] in its largest dimension by CT scan or magnetic resonance imaging [MRI])
• Availability of a representative tumor specimen and the corresponding pathology report for retrospective central confirmation of the diagnosis of FL or DLBCL

You may not qualify if…

• Known CD20-negative status at relapse or progression
• Prior allogeneic stem-cell transplantation (SCT)
• Completion of autologous SCT within 100 days prior to Day 1 of Cycle 1
• Prior standard or investigational anti-cancer therapy as specified: Radioimmunoconjugate within 12 weeks prior to Day 1 of Cycle 1; Monoclonal antibody or antibody-drug conjugate within 4 weeks prior to Day 1 of Cycle 1; Radiotherapy, chemotherapy, hormonal therapy, or targeted small-molecule therapy within 2 weeks prior to Day 1 of Cycle 1
• Clinically significant toxicity (other than alopecia) from prior therapy that has not resolved to Grade less than or equal to (</=) 2 (according to National Cancer Institute Common Terminology Criteria for Adverse Events [NCI CTCAE] version 4.0) prior to Day 1 of Cycle 1
• Grade 3b FL
• History of transformation of indolent disease to DLBCL (expansion-phase only)
• Central nervous system lymphoma or leptomeningeal infiltration
• Treatment with systemic corticosteroids >20 mg/day, prednisone or equivalent
• Clinical conditions requiring treatment with oral or parenteral anticoagulants or antiplatelet agents unless treatment can be discontinued 7 days (or 5 half-lives) prior to initiation of study treatment (except used as flushes for indwelling catheters)
• History of severe allergic or anaphylactic reaction to humanized or murine monoclonal antibodies
• Known hypersensitivity or allergy to murine products or any component of the obinutuzumab, rituximab, idasanutlin, or venetoclax formulation
• Current or history of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection: positive for hepatitis B surface antigen (HBsAg), total hepatitis B core antibody (HBcAb), or HCV antibody at screening
• History of progressive multifocal leukoencephalopathy (PML)
• History of other malignancy that could affect compliance with the protocol or interpretation of results
• Evidence of any significant, uncontrolled concomitant disease that could affect compliance with the protocol or interpretation of results
• Non-malignant medical illnesses that are uncontrolled or whose control may be jeopardized by study treatment, such as severe hereditary coagulation disorders or insulin-dependent diabetes mellitus that is not optimally controlled with medical management (example, presence of ketoacidosis)
• Major surgical procedure other than for diagnosis within 28 days prior to Day 1 of Cycle 1, or anticipation of a major surgical procedure during the study
• Inadequate hematologic function (unless due to underlying lymphoma), defined as follows: Hemoglobin less than (<) 9 grams per decilitre (g/dL), absolute neutrophil count (ANC) <1.5*10\^9 cells per liter (cells/L), platelet count <75*10\^9 cells/L
• Any of the following abnormal laboratory values (unless due to underlying lymphoma): International normalized ratio (INR) or prothrombin time (PT) >1.5*upper limit of normal (ULN) in the absence of therapeutic anticoagulation; partial thromboplastin time (PTT) or activated partial thromboplastin time (aPTT) >1.5*ULN in the absence of a lupus anticoagulant
• Life expectancy <3 months

Where it is running

• University of Colorado — Aurora, Colorado, United States
• The University of Chicago Medical Center — Chicago, Illinois, United States
• Norton Cancer Institute - Dutchmans — Louisville, Kentucky, United States
• Mount Sinai Medical Center — New York, New York, United States
• Allegheny General Hospital — Pittsburgh, Pennsylvania, United States
• Guthrie Clinic — Sayre, Pennsylvania, United States
• Swedish Cancer Inst. — Seattle, Washington, United States
• Prince of Wales Hospital — Randwick, New South Wales, Australia
• Westmead Hospital — Westmead, New South Wales, Australia
• Linear Clinical Research Limited — Nedlands, Western Australia, Australia
• Klinikum Augsburg — Augsburg, Germany
• Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden — Dresden, Germany
• SLK-Kliniken Heilbronn GmbH — Heilbronn, Germany
• Klinikum rechts der Isar der TU München — München, Germany
• Universitätsklinikum Würzburg; Studienzentrale Hämatologie/Onkologie — Würzburg, Germany
• Christchurch Hospital — Christchurch, New Zealand
• Auckland Clinical Studies Limited — Grafton, New Zealand
• Keimyung University Dongsan Medical Center — Daegu, South Korea
• Severance Hospital — Seoul, South Korea
• Asan Medical Center — Seoul, South Korea
• Samsung Medical Center — Seoul, South Korea

Full record on ClinicalTrials.gov

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