PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy
Completed · Phase 2
Conditions studied: Carcinoma, Basal Cell
In brief
The primary objective is to estimate the objective response rate (ORR) for metastatic Basal Cell Carcinoma (BCC) (group 1) and for unresectable locally advanced BCC (group 2) when treated with cemiplimab as a monotherapy
Key facts
- Study ID
- NCT03132636
- Run by
- Regeneron Pharmaceuticals
- People needed
- 138
- Starts
- 2017-06-29
- Expected to finish
- 2023-04-27
- Last updated by the study team
- 2025-04-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mayo Clinic Arizona - Mayo Clinic Hospital — Phoenix, Arizona, United States
- UC San Diego Moores Cancer Center — La Jolla, California, United States
- Stanford Medicine Outpatient Center - Stanford Dermatology Clinic-Stanford University School of Medicine — Redwood City, California, United States
- UCSF Helen Dillion Family Cancer Care Center — San Francisco, California, United States
- University of Colorado Hospital, Anschutz Outpatient Pavilion — Denver, Colorado, United States
- Mount Sinai Comprehensive Cancer Center — Miami, Florida, United States
- H Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
- Northwestern Medical Faculty Foundation — Chicago, Illinois, United States
- Norton Cancer Institute — Louisville, Kentucky, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Dana Farber Cancer Institute (DFCI) — Boston, Massachusetts, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- Atlantic Health System / Morristown Medical Center — Morristown, New Jersey, United States
- Overlook Medical Center — Summit, New Jersey, United States
- New York University School Of Medicine, Kaplan Comprehensive Cancer Center — New York, New York, United States
- Mount Sinai Hospital — New York, New York, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- James Cancer Hospital and Solove Research Institute — Columbus, Ohio, United States
- Penn State Hershey Medical Center — Hershey, Pennsylvania, United States
- Clinical Research Center of the Carolinas — Charleston, South Carolina, United States
- University of Texas MD Anderson Cancer Center — Houston, Texas, United States
- Huntsman Cancer Institute — Salt Lake City, Utah, United States
- LKH - Universitaetsklinikum Graz — Graz, Styria, Austria
- Medizinische Universitaet Innsbruck, Universitaetsklinik fuer Dermatologie, Venerologie und Allergologie — Innsbruck, Austria
- The University of Arizona Cancer Centre at Dignity Health — Phoenix, Arizona, United States
Full record on ClinicalTrials.gov
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