Inspiratory Muscle Training Post-Liver Transplant

Completed · Not applicable

Conditions studied: Liver Disease Chronic, Muscle Weakness, Respiratory Insufficiency

In brief

Individuals with chronic liver disease develop significant muscle wasting that remains post-liver transplant. The transplant surgery additionally challenges respiratory mechanics. Respiratory muscle strength has been measured to be impaired in individuals post liver transplant. This study proposes an 8 week intervention designed to increase respiratory muscle strength and pulmonary function that we hypothesize will correlate to improved functional performance and quality of life post-liver transplant. Pre-test post-test design, that will randomize subjects into an experimental group that will receive the inspiratory muscle strengthening exercise in addition to usual post-liver transplant care and a control group that will only receive the usual post-transplant care. Up to 50 subjects will be recruited from the Post-Liver Transplant Outpatient Clinic at the Miami Transplant Institute. The subjects will have repeated measurements of respiratory muscle strength, pulmonary function, functional mobility performance, and quality of life at baseline, 4 weeks, and 8 weeks.

Key facts

Study ID

NCT03130608

Run by

University of Miami

People needed

37

Starts

2017-06-30

Expected to finish

2021-05-31

Last updated by the study team

2021-06-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects must have undergone liver transplantation for chronic liver disease of any origin other than cancer.

You may not qualify if…

• Severe cardiopulmonary disease such as recent Myocardial infarction, Congestive Heart Failure, Pulmonary edema, Chronic Obstructive Pulmonary Disease, and Asthma,
• Severe osteoarthritis
• Blindness
• Wheelchair bound individuals
• Individuals with neurological / neuromuscular disorders including but not limited to: cerebral vascular accident, Parkinsonism, Alzheimer's disease, dystonia, multiple sclerosis, and polio.
• Severe Cognitive impairment where individuals cannot follow commands and are unable to sign informed consent -

Where it is running

• Miami Transplant Institute — Miami, Florida, United States

Full record on ClinicalTrials.gov

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