Trauma Induced Coagulopathy and Inflammation

Completed

Conditions studied: Trauma Injury, Trauma, Coagulopathy

In brief

While a number of factors are known to be associated with the development of trauma induced coagulopathy (TIC), inflammation, and multi-organ failure, we currently cannot predict which patients are at risk for developing these life threatening conditions with any certainty. In this prospective observational study, we will investigate the many factors that contribute to the development of trauma induced coagulopathy, post injury inflammation and the development of organ dysfunction in order to develop a multi scale computational algorithm of clinical prediction. Using a convenience sample technique, demographic data, physiologic data, blood samples and clinical variables will be collected over 5 days following traumatic injury. A computational model will be used to predict the development of TIC and multi-organ failure.

Key facts

Study ID

NCT03128658

Run by

University of Pennsylvania

People needed

300

Starts

2017-02-27

Expected to finish

2020-12-31

Last updated by the study team

2021-03-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Injured patients presenting to the trauma bay with a trauma alert activation (highest level of activation)
• Age 18 years old or more

You may not qualify if…

• Transfer duration to trauma service exceeding 6 hours.
• Known pregnancy

Where it is running

• Penn Presbyterian Medical Center — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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