A Study of Memory, Thinking, and Brain Imaging in Adults With Histiocytosis

Running, not enrolling

Conditions studied: Histiocytosis

In brief

The purpose of this study is to try to understand how histopcytosis can cause symptoms or problems in the brain. The tests being done in the study will look at memory and thinking as well as brain function via MRI scan.

Key facts

Study ID

NCT03127709

Run by

Memorial Sloan Kettering Cancer Center

People needed

13

Starts

2017-04-07

Expected to finish

2027-04-01

Last updated by the study team

2026-05-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than or equal to 18 years.
• Fluency in English
• Diagnosis of a histiocytic disorder as determined, in the opinion of the study PI, by a corroborating constellation of histopathology, clinical, and/or radiologic findings.
• Will undergo Standard of Care MRI.

You may not qualify if…

• Known intracranial involvement of histiocytosis (including dura, leptomeninges and brain parenchyma)
• Prior stroke or intracranial hemorrhage
• Other (non-histiocytic) intracranial neoplasm or neurological disorder deemed by the PI or Co-PI to confound neuroimaging studies (e.g., demyelinating disease)
• Existing diagnosis of a psychiatric disorder or untreated mood disturbance
• Existing diagnosis of a neurodegenerative disease, such as Alzheimer's disease
• Chronic or daily excessive alcohol consumption as determined by the PI.
• History of chronic use of corticosteroids, defined as continuous treatment for six months or longer at any time in the past
• History of severe claustrophobia or other contraindications to patient SOC brain MRI
• Prior intravenous cytarabine or cladribine
• Other current or prior treatments (e.g., high-dose chemotherapy for a different cancer) deemed by the PI or Co-PI to confound imaging studies or cognitive performance

Where it is running

• Memorial Sloan Kettering Basking Ridge — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth — Middletown, New Jersey, United States
• Memorial Sloan Kettering Cancer Center @ Suffolk — Commack, New York, United States
• Memorial Sloan Kettering Westchester — Harrison, New York, United States

Full record on ClinicalTrials.gov

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