A Study for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients

Running, not enrolling · Not applicable

Conditions studied: Prostate Cancer, Cardiovascular Disease

In brief

RADICAL PC1 is a prospective cohort study of men with a new diagnosis of prostate cancer. RADICAL PC2 is a randomized, controlled trial of a systematic approach to modifying cardiovascular and lifestyle risk factors in men with a new diagnosis of prostate cancer.

Key facts

Study ID

NCT03127631

Run by

McMaster University

People needed

5000

Starts

2015-10-21

Expected to finish

2026-12-31

Last updated by the study team

2026-07-02

Who can join

Age: 45 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• A man with a diagnosis of prostate cancer that is either:
• new (i.e. the diagnosis was made within 1 year of the enrolment visit) or
• treated with Androgen Deprivation Therapy for the first time within 6 months prior to the enrolment visit, or
• to be treated with Androgen Deprivation Therapy for the first time within 1 month after the enrolment visit

You may not qualify if…

• Patients will be excluded if they fulfill any of the following:
• are unwilling to provide consent or
• are <45 years of age, or
• prostate cancer was found incidentally following cystectomy for bladder cancer
• Patients will be eligible for RADICAL PC1, but will not be eligible for RADICAL PC2 if they:
• see a cardiologist every year, or
• both take a statin and have systolic blood pressure ≤130mmHg

Where it is running

• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• UT Southwestern Medical Center — Dallas, Texas, United States
• Westmead Hospital — Westmead, New South Wales, Australia
• Royal Adelaide Hospital — Adelaide, South Australia, Australia
• Flinders Medical Center — Adelaide, South Australia, Australia
• Centro de Pesquisa Clínica do Brasil — Brasília, Federal District, Brazil
• Hospital Felício Rocho — Belo Horizonte, Minas Gerais, Brazil
• Universidade Federal do Triângulo Mineiro — Uberaba, Minas Gerais, Brazil
• Sociedade Hospitalar Angelina Caron — Campina Grande do Sul, Paraná, Brazil
• Nucleo de Pesquisa Clinica Hospital do Rocio — Campo Largo, Paraná, Brazil
• Centro Médico São Francisco — Curitiba, Paraná, Brazil
• Instituto De Medicina Integral Prof. Fernando Figueira - IMIP — Recife, Pernambuco, Brazil
• Instituto Nacional de Cardiologia — Rio de Janeiro, Rio de Janeiro, Brazil
• Hospital de Caridade de Ijuí — Ijuí, Rio Grande do Sul, Brazil
• Hospital de Clínicas de Porto Alegre — Porto Alegre, Rio Grande do Sul, Brazil
• Irmandade Da Santa Casa De Misericórdia De Porto Alegre — Porto Alegre, Rio Grande do Sul, Brazil
• Hospital Mae de Deus — Porto Alegre, Rio Grande do Sul, Brazil
• Hospital Municipal de Barueri — Barueri, São Paulo, Brazil
• Faculdade de Medicina da Universidade Estadual Paulista - Campus de Botucatu - UNESP — Botucatu, São Paulo, Brazil
• Hospital Universitário São Francisco na Providência de Deus — Bragança Paulista, São Paulo, Brazil
• Fundacao Doutor Amaral Carvalho — Jaú, São Paulo, Brazil
• Fundação Faculdade Regional de Medicina de São José do Rio Preto — São José do Rio Preto, São Paulo, Brazil
• Santa Casa de São Paulo (IPITEC) — São Paulo, São Paulo, Brazil
• Georgia Cancer Center at Augusta University — Augusta, Georgia, United States

Full record on ClinicalTrials.gov

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