AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Completed · Phase 2 · Has a placebo group
Conditions studied: Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Neuromuscular Diseases, Neurodegenerative Diseases, Spinal Cord Diseases, TDP-43 Proteinopathies, Nervous System Diseases, Central Nervous System Diseases
In brief
The CENTAUR trial was a 2:1 (active:placebo) randomized, double-blind, placebo-controlled Phase II trial to evaluate the safety and efficacy of AMX0035 for the treatment of ALS.
Key facts
- Study ID
- NCT03127514
- Run by
- Amylyx Pharmaceuticals Inc.
- People needed
- 137
- Starts
- 2017-06-22
- Expected to finish
- 2019-11-24
- Last updated by the study team
- 2024-05-16
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Barrow Neurological Institute — Phoenix, Arizona, United States
- UC Irvine Medical Center — Orange, California, United States
- Forbes Norris MDA/ALS Research Center - California Pacific Medical Center — San Francisco, California, United States
- University of Florida Medical Center — Gainesville, Florida, United States
- Carol and Frank Morsini Center for Advanced Health Care - University of South Florida — Tampa, Florida, United States
- Emory University Hospital — Atlanta, Georgia, United States
- University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
- University of Kentucky Medical Center — Lexington, Kentucky, United States
- Ochsner Neuroscience Institute — New Orleans, Louisiana, United States
- Johns Hopkins Hospital — Baltimore, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- University of Massachusetts Memorial Medical Center — Worcester, Massachusetts, United States
- University of Michigan Medical Center — Ann Arbor, Michigan, United States
- Hennepin County Medical Center — Minneapolis, Minnesota, United States
- Washington University Medical Center — St Louis, Missouri, United States
- Neurology Associates P.C. — Lincoln, Nebraska, United States
- Mount Sinai Beth Israel — New York, New York, United States
- Wake Forest Baptist Medical Center — Winston-Salem, North Carolina, United States
- The Ohio State University Wexner Medical Center — Columbus, Ohio, United States
- Oregon Health & Science University — Portland, Oregon, United States
- The Penn Comprehensive ALS Center — Philadelphia, Pennsylvania, United States
- Temple University Hospital — Philadelphia, Pennsylvania, United States
- Texas Neurology, P.A. — Dallas, Texas, United States
- University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
- ALS Center at the Swedish Neuroscience Institute — Seattle, Washington, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.