Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Amyotrophic Lateral Sclerosis
In brief
The objective is to compare the efficacy and safety of masitinib in combination with riluzole versus matched placebo in combination with riluzole for the treatment of Amyotrophic Lateral Sclerosis (ALS).
Key facts
- Study ID
- NCT03127267
- Run by
- AB Science
- People needed
- 495
- Starts
- 2021-02-02
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2025-09-12
Who can join
Age: 18 and older, up to 81. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States (enrolling)
- University of Kentucky — Lexington, Kentucky, United States (enrolling)
- Johns Hopkins Medicine Brain Science Institute — Baltimore, Maryland, United States (enrolling)
- University of Southern California — Los Angeles, California, United States (enrolling)
- University of Virginia Health System — Charlottesville, Virginia, United States (enrolling)
- University Hospital Leuven (UZ Leuven) — Leuven, Belgium (enrolling)
- Bispebjerg Hospital — Copenhagen, Denmark (enrolling)
- CHU de Angers — Angers, France (enrolling)
- Lahey Hospital and Medical Center — Burlington, Massachusetts, United States (enrolling)
- Hôpital neurologique Pierre Wertheimer — Bron, France (enrolling)
- CHU Gabriel Montpied — Clermont-Ferrand, France (enrolling)
- CHU de Lille - Hopital Roger Salengro — Lille, France (enrolling)
- CHU de Limoges - Hôpital Dupuytren — Limoges, France (enrolling)
- CHU de Marseille - Hôpital de la Timone — Marseille, France (enrolling)
- CHRU de Montpellier - Gui de Chauliac — Montpellier, France (enrolling)
- CHU de Nancy - Hopital Central — Nancy, France (enrolling)
- CHU Hôpital Pasteur Nice — Nice, France (enrolling)
- CHRU de Tours - Hopital Bretonneau — Tours, France (enrolling)
- Groupe Hospitalier Pellegrin Tripode — Bordeaux, France (enrolling)
- Athens Naval Hospital — Athens, Greece (enrolling)
- Eginition Hospital — Athens, Greece (enrolling)
- University General Hospital of Larissa — Larissa, Greece (enrolling)
- General University Hospital of Patras — Rio, Greece (enrolling)
- Hadassah University Hospital — Jerusalem, Israel (enrolling)
- Tel-Aviv Medical Center Hôpital Sourasky (ICHILOV) — Tel Aviv, Israel (enrolling)
Full record on ClinicalTrials.gov
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