Cognitive Regulation Training and Exercise Trial

Completed · Not applicable

Conditions studied: Patient Compliance

In brief

The purpose of this double-blinded, randomized controlled study is to compare CORTEX (Cognitive Regulation Training and Exercise), a multi-faceted, center- and home-delivered- general and exercise-specific-active and traditional computerized cognitive training (CT) program to an attention-control condition involving health and wellness informational videos. More specifically, the cognitive training group will emphasize dual-task abilities, working memory, and visual-spatial processing, as well as self-as-exerciser priming and self-certainty training. It is hypothesized that early intervention cognitive training will enhance use of self-regulatory strategies and self-efficacy and in turn, increase exercise adherence to and engagement in a 12-month aerobic and resistive exercise program at a local fitness facility. More positive improvements in cognitive and psychosocial functioning among participants in the CORTEX condition (relative to the Video Attention-Control condition, i.e., health educational videos), are also expected immediately following the cognitive training, and across time. Expectancies and knowledge of study purpose (blinding integrity) will also be measured and used to statistically adjust for any training differences.

Key facts

Study ID

NCT03124667

Run by

University of Illinois at Urbana-Champaign

People needed

233

Starts

2017-01-01

Expected to finish

2020-10-10

Last updated by the study team

2020-12-10

Who can join

Age: 35 and older, up to 64. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women
• Low active for the past 3 months
• 35 to 64 years old
• Do NOT regularly play exergames (e.g., XBox Kinect, Playstation Move, Nintendo Wii)
• Do NOT engage in "brain training" regularly (less than once per week)
• Are NOT enrolled in another exercise program or cognitive training study
• Able and willing to comply with the study length, testing, training and exercise program requirements
• Lives within 20 miles of the fitness facility and UIUC research facility
• Has reliable at-home Wi-Fi internet access and an available port for plugging in XBox console
• Vision is at least 20/40 with glasses or contacts with no color blindness
• Do NOT have depression (as defined by a score of 2 or less on the abbreviated Geriatric Depression Scale [GDS-5])
• Do NOT have cognitive impairment (as defined by a score of 21 or higher on the Telephone Interview Cognitive Survey [TICS])

You may not qualify if…

• Previously involved in the first CORTEX trial
• Currently involved in regular weekly cognitive training or another physical activity program or study (e.g., yoga, meditation)
• Too active (as defined by regularly exercise 2 or more days per week for 30+ minutes over the past 3 months)
• Incapable of performing moderately intensive aerobic exercise (must be able to complete basic movements, i.e., walking, jogging, jumping, side-stepping, throwing, kicking, punching, grabbing) without exacerbating a pre-existing condition caused by overuse, surgery, or other chronic condition
• Unable or unwilling to comply to lab and home-based training and physical activity prescription
• Unable to commit to full length of program
• Unwilling to be randomized to one of two groups
• Home residence exceeds 20 mile radius from fitness facility or unable to commute to and from fitness facility and UIUC campus
• Do not have reliable at-home Wi-Fi internet access or a required port for plugging in Xbox
• Uncorrectable vision (i.e., less than 20/40 with glasses or contacts with color blindness)
• Depression as defined by GDS >2
• Cognitive impairment as defined by TICS < 21

Where it is running

• University of Illinois — Urbana, Illinois, United States

Full record on ClinicalTrials.gov

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