A Study of B-701 in Combination With Pembrolizumab in Treatment of Locally Advanced or Metastatic Urothelial Cell Carcinoma
Stopped early · Phase 1/Phase 2
Conditions studied: Locally Advanced or Metastatic Urothelial Cell Carcinoma, Urinary Bladder Disease, Urological Diseases
In brief
This is a Phase 1b/2 multi-center, open-label study to establish the initial safety and to determine a recommended Phase 2 dose of B-701 in combination with pembrolizumab, and to determine safety, tolerability and efficacy of B-701 (vofatamab) plus pembrolizumab in the treatment of subjects with locally advanced or metastatic UCC, who have progressed following platinum-based chemotherapy and who have not received prior immune checkpoint inhibitor therapy.
Key facts
- Study ID
- NCT03123055
- Run by
- Rainier Therapeutics
- People needed
- 28
- Starts
- 2017-04-20
- Expected to finish
- 2019-12-01
- Last updated by the study team
- 2020-03-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Research Site — Fort Wayne, Indiana, United States
- Research Site — Louisville, Kentucky, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- Research Site — Cleveland, Ohio, United States
- Research Site — Philadelphia, Pennsylvania, United States
- Research Site — Germantown, Tennessee, United States
- Research Site — Houston, Texas, United States
- Research Site — Brussels, Belgium
- Research Site — Leuven, Belgium
- Research Team — Yvoir, Belgium
- Research Team — Copenhagen, Denmark
- Research Site — Bordeaux, France
- Research Site — Dijon, France
- Research Site — Dresden, Germany
- Research Site — Frankfurt, Germany
- Research Site — Heidelberg, Germany
- Research Site — Kassel, Germany
- Research Site — Munich, Germany
- Research Site — Münster, Germany
- Research Site — Budapest, Hungary
- Research Site — Milan, Italy
- Research Site — Milan, Italy
- Research Site — Chisinau, Moldova
- Research Site — Utrecht, Netherlands
- Research Site — Greenbrae, California, United States
Full record on ClinicalTrials.gov
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