TCA Cycle in the Dentate in Friedreich's Ataxia

Completed

Conditions studied: Friedreich Ataxia

In brief

OBJECTIVE: To measure the tricarboxylic acid (TCA) cycle rate in the dentate nucleus in a group of control subjects and subjects with Friedreich's Ataxia (FRDA). HYPOTHESIS: The TCA cycle rate will be lower in FRDA subjects than in controls APPROACH: The investigators will infuse carbon-13 (13C) labeled glucose and measure the rate of 13C label incorporation from glucose to glutamate in the brain using in vivo magnetic resonance spectroscopy.

Key facts

Study ID

NCT03122925

Run by

University of Minnesota

People needed

20

Starts

2017-08-29

Expected to finish

2023-01-11

Last updated by the study team

2023-03-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 years of age or older
• able to consent for themselves
• considered healthy (controls) OR be diagnosed with FRDA.

You may not qualify if…

• All subjects:
• Participants who cannot have an MRI, as determined by the CMRR safety screening form (e.g. metal implant)
• Pregnancy
• Clautrophobia
• Diabetes
• Clinically significant cardiac disease
• Control subjects:
• Neurological disease

Where it is running

• CMRR — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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