TLR4 Polymorphisms and Risk of Skin Cancer

Completed

Conditions studied: Skin Cancer

In brief

Toll-like receptors (TLRs) play a key role in the innate immune system. Toll-like receptor-4 (TLR4) in particular, appears to play a role in susceptibility to cancer. Of 44 identified SNPs (small nucleotide polymorphisms) in TLR4, the most common is an A-G substitution at nucleotide position +896, downstream of the cDNA start codon, a missense mutation which leads to an amino acid substitution Asp299Gly in the third exon of the TLR4 gene. Pre-clinical studies from our laboratory have shown an association of TLR4 with ultraviolet radiation induced skin cancer. Hence, in this study we will assess the pattern of TLR4 polymorphisms and susceptibility to skin cancer.

Key facts

Study ID

NCT03122366

Run by

University of Alabama at Birmingham

People needed

392

Starts

2009-02-02

Expected to finish

2011-09-27

Last updated by the study team

2023-03-22

Who can join

Age: 50 and older, up to 99. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female over the age of 50
• Fitzpatrick skin type I-IV

You may not qualify if…

• Tumor types other than basal cell carcinoma, squamous cell carcinoma and melanoma
• Chronic immunosuppression due to transplant antirejection regimen or HIV/AIDS
• Nevoid basal cell carcinoma syndrome, Cowden's syndrome, xeroderma pigmentosum or other syndrome with skin-cancer predisposition
• Known exposure to arsenic or ionizing radiation

Where it is running

• The Kirklin Clinic — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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