Combining tDCS and Neurorehabilitation to Treat Age-related Deficits of Mobility and Cognition: UPfront Walking Study

Completed · Not applicable · Has a placebo group

Conditions studied: Mobility Limitation, Cognitive Impairment

In brief

Loss of mobility and cognitive ability are serious conditions that threaten the independence of older adults. The objective of this study is to initiate a line of research to develop a novel therapeutic intervention to enhance both mobility and cognition via neuroplasticity of frontal/executive circuits.

Key facts

Study ID

NCT03122236

Run by

University of Florida

People needed

20

Starts

2017-06-01

Expected to finish

2021-03-06

Last updated by the study team

2024-06-14

Who can join

Age: 65 and older, up to 110. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• preferred 10m walking speed < 1.0 m/s
• 40th-80th percentile rank (age and education corrected score) on NIH toolbox executive assessments: Card Sort Test and Flanker test
• willingness to be randomized to either intervention and to participate in all aspects of study assessment and intervention

You may not qualify if…

• contraindications to non-invasive brain stimulation and/or MRI including metal in the head, pacemaker, known abnormal cranial fissures/holes.
• difficulty communicating with study personnel
• uncontrolled hypertension at rest (systolic > 180 mmHg and/or diastolic > 100 mmHg)
• low vision that cannot be corrected by wearing glasses. Low visual will be operationally defined as visual acuity less than 20/70 on a standard eye chart, or difficulty performing complex walking tasks due to visual conditions affecting accurate navigation around and over obstacles (self-reported or observed by examiner).
• illiterate, due to the likelihood of difficulties performing some of the cognitive tasks
• non-English speaking, due to the likelihood of difficulties following instructions during therapy and during assessments
• use of medications that are know to modify tDCS effectiveness including those with anticholinergic, GABAergic, or glutamatergic properties, or sodium channel blockers
• clinical judgment of investigative team

Where it is running

• HealthStreet — Gainesville, Florida, United States
• UF Institute on Aging — Gainesville, Florida, United States
• University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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