Functional Imaging in Lung SBRT

Completed

Conditions studied: Lung Cancer

In brief

Little is known about the safety of body radiation therapy (SBRT), especially the impact on pulmonary function, quality of life, and on functional changes within the lung itself. Radiation dose constraints and capturing functional changes on imaging are not well studied in this setting. The current study aims to evaluate the utility of advanced imaging to measure lung function prior to and after treatment and to assess the feasibility of using this data to adapt SBRT planning.

Key facts

Study ID

NCT03121300

Run by

University of Michigan Rogel Cancer Center

People needed

33

Starts

2017-02-06

Expected to finish

2019-08-30

Last updated by the study team

2019-10-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients receiving SBRT lung treatment and who have any one of the following high risk features:
• Lung lesion > 5 cm
• DLCO < 35%
• FEV1 < 0.5 L
• Central lung tumors (defined as within 2 cm from the proximal bronchial tree)
• Tumors that abut the great vessels, trachea, spinal cord, or esophagus
• Prior lobectomy or pneumonectomy
• Prior lung radiation (SBRT or conventional definitive lung radiation)
• Patients must be 18 years of age or older

You may not qualify if…

• Patients who have received targeted agents or systemic potentially radiosensitizing chemotherapy within 2 weeks of lung SBRT start
• Pregnancy or lactation
• Unable to tolerate MRI without anesthesia
• Inability cooperate with the scans

Where it is running

• University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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